MATERIALS AND METHODS: We used a non-lethal and two different lethal models of cyanide poisoning in mice. We now asked if the two drugs would have an augmented effect when combined. Both drugs can be given by intramuscular administration, and therefore could be used to treat a large number of people quickly. OBJECTIVE: We are developing two new cyanide antidotes-cobinamide, a vitamin B(12) analog, and sulfanegen, a 3-mercaptopyruvate prodrug. Current therapies for cyanide poisoning must be given by intravenous administration, limiting their use in treating mass casualties. Moreover, cyanide has the potential to be used by terrorists, particularly in a closed space such as an airport or train station. CONTEXT: Cyanide is a component of smoke in residential and industrial fires, and accidental exposure to cyanide occurs in a variety of industries.
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